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doi: 10.1111/hepr.12720 28

All experiments conformed to the principles set out in the World Medical Association Declaration of Helsinki and the Department of Health and Human Services Belmont Report

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Starting from the damaging effects of radical species that formerly gave the ascertain of their involvement in muscle functions we now have the knowledge that ROS/RNS are fundamental for proper muscle physiology, as part of redox-mediated signaling pathways, and that derangement in their production participates in muscle aging and dysfunctions